"It's not really my decision," said Grosjean, speaking to reporters at the Rueil-Malmaison exhibition. "It's my body that has made me take it."
The Marseille-born player who has made his home in Florida for the past decade, has been plagued by injuries in recent times and has seen his world ranking plummet to 546.
Four times a major semi-finalist - including twice at Wimbledon in 2003 and 2004 – he revealed his ailments had left him with little other option but to call time on his career.
"I am going to stop playing at the end of the season," he stated. "It is not really my decision, it is my body that has persuaded me it is time to do so."
Grosjean went on to reveal that he has not requested a wildcard entry for the forthcoming French Open because of fitness concerns, although he will compete in the doubles at Roland Garros with compatriot Richard Gasquet.
"I did not ask for a wild card for the singles tournament because I am not ready physically for a five-set match and I did not want to take the place of a young player," he added.
Grosjean won a total of four ATP titles, including Bercy in 2001 which secured him a place at the season-ending Masters Cup tournament in Sydney where he was defeated by Australian Lleyton Hewitt in the final.